Interés terapéutico del fruto cardo mariano / Therapeutic interest of milk thistle fruit

La actividad antipatotóxica del fruto de cardo mariano y de la silimarina es conocida desde hace muchos años. Su efecto positivo sobre el hígado está basado en las acciones antioxidante, estabilizadora de membrana, favorecedora de la síntesis proteica, antivirásica, antiinflamatoria, inmunomoduladora y anticolestásica de la silimarina y su principal componente, la silibinina. Su eficacia clínica ha sido demostrada en distintos tipos de alteraciones hepáticas, principalmente en las producidas por alcohol y las causadas po virus. Diversos estudios han establecido el papel quimiopreventivo de la silimarina y de la silibinina en distintas áreas celulares cancerosas, así como su efecto estimulante sobre la secreción láctea, además de su actuación en otros ámbitos (protección ósea, neuroprotección, aterogénesis, etc.). a este conjunto de datos, que apuntan hacia posibles nuevas aplicaciones de los productos obtenidos a partir del cardo mariano, se une su amplio margen terapéutico y su baja toxicidad (AU)

Antihepatotoxic activity of milk thistle fruit and silymarin has been known for many years. The positive effect on the liver is based on the antioxidant, membrane stabilizing, protein synthesis increase, antiviral, anti-inflammatory, immunomodulatory and anticolestatic actions of sylimarin and its major constituten, silybinin. Its clinical efficacy has been shown in several types for liver disorders, namely those produced by alcohol and those caused by virus. Several studies have established the chemopreventive role of sylimarin and silybinin in different cancer cell lines and its stimulating effect on lactation, as well as their beneficial effects in other areas (bone protection, neuroprotection, atherogenesis,e tc.). All these data point to possible new applications of the products derived from milk thistle that, in addition, show a wide therapeutic range and low toxicity (AU)

Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat

An herbal extract mixture and yogurt added to the herbal extract mixture were tested for their protective and therapeutic effects on ethanol-induced liver injury. The herbal extract mixture, yogurt and commercial drugs were used for treatment for two weeks prior to administering a single oral dose of ethanol (3 g/kg body weight). The herbal extract mixture and yogurt added to the herbal extract mixture were found to provide protection against ethanolinduced toxicity comparable to the commercial drug treatment, according to the serum and histopathological analysis. It was also shown that co-treatment with herbal extract mixture and yogurt against a triple oral dose of ethanol (2 g/kg body weight, over one week) provided protection against ethanol toxicity. After the initial set of experiments, the herbal extract mixture and yogurt treatments were extended for three more weeks. When compared to the positive control, further treatment with both the herbal extract and yogurt significantly reduced liver injury and resulted in a lower grade of lipid deposition.

Control de calidad de residuos de biocidas en frutos de Silybum marianum L / Quality control of organochlorine biocide residues in fructus from Silybum marianum L

Los estudios analíticos de los biocidas organoclorados demuestran que su nivel de concentración en las raíces de plantas es mayor que la concentración en el suelo, y especialmente en las plantas medicinales utilizadas en las industrias farmacéutica y medicinal. Los fármacos búlgaros más utilizados (Carsil, Tribestan y Nivalin) contienen extractos de plantas y deben ser analizados de acuerdo con las directivas de la Comunidad Europea EEC/76/895 y EEC/90/642 1998; Por ello, se ha estudiado el método de cromatografía de gases para la determinación cuantitativa de biocidas organoclorados (HCH e isómeros, DDT y metabolitos). Se han analizado conforme a las regulaciones de la Pharmacopoeia Europea materiales procedentes de plantas de distintas regiones de Bulgaria (frutos de Silybum marianum, L) y grageas de Carsil producidas por Sopharma Ltd. El método ha sido validado y se han estudiado parámetros analíticos de especificidad, linealidad, precisión, replicabilidad y rango

Analytical studies of organochlorine biocides show that their concentration in the plants (roots) is higher than in the ground and particularly in the medicinal plants used in the therapy and the pharmacy industry. The most favorite Bulgarian drugs (Carsil, Tribestan and Nivalin Nivalin) contain plant extracts and they have to be analyzed in respect to European Community Directives EEC/76/895 and EEC/90/642 1998; In view of that the gas chromatography method for quantitative determination of organochlorine biocides (HCH and isomers, DDT and metabolites) was studied. Plant material from different regions of Bulgaria (fructus from Silybum marianum, L) and Carsil dragee produced by Sopharma Ltd. were analyzed in respect to European Pharmacopoeia regulations. The method was validated and analytical parameters specificity, linearity, precision, repeatability and range were studied